RNA

Part:BBa_K1728005

Designed by: Yung-Li Chen, Zih-Yu Liu, Cheng-Hsiung Hsu   Group: iGEM15_CGU_Taiwan   (2015-09-17)

IL1β partial sequence

IL1β; partial sequence

Usage and Biology

This part is a partial sequence of Interleukin-1β(IL-1β)mRNA and act as a transcription resource of oral cancer marker mRNA.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


MIT_MAHE 2020

Summary Interleukin-1β (IL-1β), belongs to the interleukin-1 (IL-1) cytokine family. It is a pro-inflammatory cytokine and key in mediating body's responses to microbial infection, immunological reactions, and tissue injury. Processing of IL-1β precursor to active form can be done using various proteases. It is involved in mediating inflammation, initiating or increasing a wide variety of non-structural, function associated genes that are usually expressed during inflammation. There are now full cDNA sequences and genomic organisation of IL-1 beta taken from bird, amphibian, bony fish and cartilaginous fish, with many of these genes having been obtained using an homology cloning approach [1,2].

References

1. Husain, M., Bird, S., van Zwieten, R., Secombes, C. J., & Wang, T. (2012). Cloning of the IL-1β3 gene and IL-1β4 pseudogene in salmonids uncovers a second type of IL-1β gene in teleost fish. Developmental and comparative immunology, 38(3), 431–446. https://doi.org/10.1016/j.dci.2012.07.010

2. Bird, S., Zou, J., Wang, T., Munday, B., Cunningham, C., & Secombes, C. J. (2002). Evolution of interleukin-1beta. Cytokine & growth factor reviews, 13(6), 483–502. https://doi.org/10.1016/s1359-6101(02)00028-x

[edit]
Categories
//collections/immune_regulation/inflammatory
Parameters
None